Protein and peptide drugs: Many protein and peptide drugs, such as insulin, growth hormone, etc., have poor stability in solution and are prone to degradation, aggregation, and other phenomena. Through vacuum freeze-drying technology, these drugs can be made into freeze-dried formulations that can be stored in a low-temperature, dry state for a long time, maintaining their biological activity and stability. For example, recombinant human growth hormone for injection is made using vacuum freeze-drying technology, widely used in clinical applications, convenient for storage and transportation, and can quickly restore its activity after reconstitution.

Vaccines: Vaccines are important products in the field of biopharmaceuticals and require strict storage conditions. Vacuum freeze-drying technology can remove moisture from vaccines, reduce the metabolic activity of microorganisms in vaccines, and improve the stability and shelf life of vaccines. For example, various vaccines such as influenza vaccine and rabies vaccine are processed using vacuum freeze-drying technology during the production process, in order to store and transport them under different environmental conditions, ensuring that the vaccines still have good immunogenicity during use.

Traditional Chinese Medicine Preparations: Some effective ingredients or compound preparations of traditional Chinese medicine also use vacuum freeze-drying technology. For example, Ginkgo biloba leaf extract is prepared into freeze-dried powder injections, which are continuously placed under high temperature, high humidity and other conditions for 10 days without significant changes in various indicators. This solves the problem of some traditional Chinese medicine formulas or prescriptions that require intravenous injection but are unstable in water in clinical applications. At the same time, the texture is loose and can be quickly dissolved after adding water.

Liposome drugs: Liposomes are a commonly used drug carrier, but liquid liposomes have poor stability and are prone to coagulation, fusion, and other phenomena. Preparing liposomes into freeze-dried powder can improve their stability and storage life. If the nano suspension of total flavonoids in Pueraria lobata is prepared into freeze-dried powder, its solubility, stability, and bioavailability can be significantly improved; The preparation of bufotalin into liposome freeze-dried powder has a loose structure, full appearance, uniform color, and good rehydration properties.